there is a whole chapter (3.8.1) in Mellanox WinOF user-manula that will gouide you through setting general perfromance optimization and tuning
single port traffic (for example, in CX-3) is when you define physical or virtual capabilities of traffic over a single port of the NIC and improves performance for running single port traffic each time.
A single stream traffic is used to get maximum bandwidth and decrease the CPU utilization , allowing sending in higher rate. this mainly optimizes tuning for applications with single connection
It is not recommended, but you can "tune" each port's parameter manually & differently over adapter's properties --> advanced and also within Registry-key tuning but having different port tunigs of the same adapter - you are likely to get inconsistent performance of the entire NIC